In our recent webinar titled “PK-PD in support of accelerated programmes for antimicrobial development: how much is enough?” with William Hope, we received more questions from the audience than we could answer during the session. We will now follow up on some remaining questions in the forum and encourage our experts but also users to discuss these questions.
The in vitro testing of the influence of protein binding on the activity has several pitfalls and confounding factors and test conditions have to be considered, e.g. source of protein, concentration of the tested antibiotic, temperature, pH, electrolytes and supplements. A summary of the issues and recommendations are published here: doi: 10.1128/AAC.01433-10
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