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In vitro protein binding versus the effect of serum on MIC2018-07-18T08:47:59+00:00

Home Discussions PK-PD and dosing In vitro protein binding versus the effect of serum on MIC

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  • Community managerCommunity manager
    Keymaster
    Post count: 23

    In our recent webinar titled “PK-PD in support of accelerated programmes for antimicrobial development: how much is enough?” with William Hope, we received more questions from the audience than we could answer during the session. We will now follow up on some remaining questions in the forum and encourage our experts but also users to discuss these questions.

    Please see find a recording of this webinar here.

    One webinar participant asked: Could you explain the relation of in vitro protein binding versus the effect of serum on MIC?

    AvatarUrsula Theuretzbacher
    Expert
    Post count: 10

    The in vitro testing of the influence of protein binding on the activity has several pitfalls and confounding factors and test conditions have to be considered, e.g. source of protein, concentration of the tested antibiotic, temperature, pH, electrolytes and supplements. A summary of the issues and recommendations are published here: doi: 10.1128/AAC.01433-10

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