In our recent webinar titled “PK-PD in support of accelerated programmes for antimicrobial development: how much is enough?” with William Hope, we received more questions from the audience than we could answer during the session. We will now follow up on some remaining questions in the forum and encourage our experts but also users to discuss these questions.
There are good UTI models available. That model would be the more relevant model one for a cUTI indication. In the case of SSTIs the most frequently used model is the murine thigh model. In addition to that there are also mouse models of skin and soft tissue infection induced by subcutaneous inoculation of S. aureus.