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PK/PD models to consolidate inconsistency between in vivo and in vitro data2018-07-18T08:55:57+00:00

Home Discussions PK-PD and dosing PK/PD models to consolidate inconsistency between in vivo and in vitro data

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  • Community managerCommunity manager
    Keymaster
    Post count: 23

    In our recent webinar titled “PK-PD in support of accelerated programmes for antimicrobial development: how much is enough?” with William Hope, we received more questions from the audience than we could answer during the session. We will now follow up on some remaining questions in the forum and encourage our experts but also users to discuss these questions.

    Please see find a recording of this webinar here.

    One webinar participant asked: Can we consolidate inconsistency between in vivo and in vitro data using PK/PD models?

    AvatarUrsula Theuretzbacher
    Expert
    Post count: 10

    There are many reasons for possible inconsistencies as in vitro systems provide an artificial environment with certain chosen concentrations. Some examples: not considering protein binding, special PK in animals or antivirulence approaches that cannot be tested using MICs. Whether PK/PD models can overcome inconsistencies depends on the individual case.

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