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What is the role of MIC for defining drug dosage?2018-07-18T08:54:05+00:00

Home Discussions PK-PD and dosing What is the role of MIC for defining drug dosage?

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  • Community managerCommunity manager
    Keymaster
    Post count: 23

    In our recent webinar titled “PK-PD in support of accelerated programmes for antimicrobial development: how much is enough?” with William Hope, we received more questions from the audience than we could answer during the session. We will now follow up on some remaining questions in the forum and encourage our experts but also users to discuss these questions.

    Please see find a recording of this webinar here.

    One webinar participant asked: How important is the role of the MIC in defining drug dosage? How can drug dosage be calculated using MIC? 

    AvatarUrsula Theuretzbacher
    Expert
    Post count: 10

    Dose finding is based on thorough in vitro and in vivo PK/PD studies. Historically, the PD input is the MIC and therefore influences the required drug exposure (free fraction) which depends on the dosage. Therefore, the MIC plays an important role as measurement of the activity of a drug. Though the MIC is routinely used it has some pitfalls (see https://doi.org/10.1093/jac/dkx427). An evaluation of a drug, especially the appropriate dose only based on MICs is inappropriate as it neglects the exposure (PK) of this drug. Monte Carlo Simulation accounts for the variability in MIC and PK and is part of the dose finding process.

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