In our recent webinar titled “PK-PD in support of accelerated programmes for antimicrobial development: how much is enough?” with William Hope, we received more questions from the audience than we could answer during the session. We will now follow up on some remaining questions in the forum and encourage our experts but also users to discuss these questions.
Dose finding is based on thorough in vitro and in vivo PK/PD studies. Historically, the PD input is the MIC and therefore influences the required drug exposure (free fraction) which depends on the dosage. Therefore, the MIC plays an important role as measurement of the activity of a drug. Though the MIC is routinely used it has some pitfalls (see https://doi.org/10.1093/jac/dkx427). An evaluation of a drug, especially the appropriate dose only based on MICs is inappropriate as it neglects the exposure (PK) of this drug. Monte Carlo Simulation accounts for the variability in MIC and PK and is part of the dose finding process.
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