Definition:
Caco-2 cell monolayer permeability model is used to predict in vivo oral absorption.
Caco-2 cells are a human colon epithelial cancer cell line. The Caco-2 cell monolayer permeability model measures the rate of flux of a compound across polarized Caco-2 cell monolayers. It has been extensively used in predicting in vivo oral absorption of natural and synthetic products in humans.
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