Animal model, efficacy

Animal models are used in drug development to generate translatable results (from animal to human) to progress drug candidates to the clinic.

For animal models used in antibacterial drug development, first a disease or condition is induced, then bacteria are inoculated and a therapy is applied. Though routine animal models provide reasonable correlation with clinical outcome, the choice of animal model, standardisation, study design, statistical analysis remain areas of concern.

See also Animal efficacy rule, Neutropenic mouse model

Assessing Animal Models of Bacterial Pneumonia Used in Investigational New Drug Applications for the Treatment of Bacterial Pneumonia (Antimicrobial Agents and Chemotherapy, 2020)

A Standardised Framework to Identify Optimal Animal Models for Efficacy Assessment in Drug Development (PLoS One, 2019)

How Preclinical Infection Models Help Define Antibiotic Doses in the Clinic (International Journal of Antimicrobial Agents, 2020)

Choosing the Right Animal Model for Infectious Diseases Research (Animal Models and Experimental Medicine, 2018)