Mathew Njoroge is a senior scientist at the Holistic Drug Discovery and Development Centre (H3D), University of Cape Town (UCT), where he works as part of a multidisciplinary team to advance preclinical drug discovery projects. His day-to-day focus is on understanding the metabolism and pharmacokinetics of compounds, with a view to translating in vitro data into human exposure–efficacy relationships. This work contributes to compound progression within H3D’s portfolio of projects in malaria, tuberculosis and antimicrobial resistance.
This work, combined with H3D’s mission to build Africa-specific models, has led to research interests in drug metabolism and disposition in African populations, with a focus on the impact of pharmacogenetic variability on drug pharmacokinetics.