Escherichia coli – REVIVE

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Drug development

CMC Discovery Exploratory Hit-to-lead Lead-to-candidate Phase 1 Phase 2 Phase 3 Phase 4 PK/PD Preclinical development Regulatory Screening Toxicology

Indication

ABSSI Bloodstream infection Gonorrhoea HAP/VAP IAI Pneumonia SSTI STI Tuberculosis UTI

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Microbe / Microbial properties

Acinetobacter baumannii Enterobacteriaceae Enterococcus faecium Escherichia coli ESKAPE Gram negative Gram positive Klebsiella pneumoniae MDR PDR Pseudomonas aeruginosa Staphylococcus aureus WHO priority pathogens XDR

Antibiotics class

Aminoglycosides Carbapenems Cephalosporins Diarylquinolines Glycopeptides Lincomycins Macrolides Penicillins Quinolones Sulfonamides Tetracyclines

Other tags

Access Diagnostics Stewardship

Combination antibiotic therapy against drug-resistant Gram-negative bacteria: where the evidence stands

Why we need to prioritize developing antibiotics for children

Discovery of new antibacterials using artificial intelligence (computational chemoinformatics)

Converting Gram-positive-only compounds into broad-spectrum antibiotics

Natural product antibiotics: from traditional screening to novel discovery approaches

Models for antimicrobial R&D: Development and use of in vivo models for infectious disease research

NIAID Resources to Facilitate Discovery & Development of Anti-Infectives

WHO priority pathogens

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