A family of Gram-negative, facultatively anaerobic, glucose-fermenting bacteria commonly found in the gastrointestinal tract. This family forms part of the Enterobacterales order of bacteria.

The most clinically relevant members of this family are Escherichia coli, Klebsiella pneumoniae, Enterobacter spp., Salmonella spp. and Shigella spp. Multidrug resistance is common among Enterobacteriaceae, with carbapenem-resistant Enterobacteriaceae (CRE) seen as a particular public health threat.