Parallel artificial membrane permeability assay (PAMPA assay)

Definition:

PAMPA is a screening tool for the evaluation of drug permeability across various biological membrane systems in a microplate format.

This assay has been established to predict intestinal drug uptake into humans. Analogous assays for studying uptake into bacteria are not well established.

See also: Caco-2 cell permeability

More information:

Real-Time Parallel Artificial Membrane Permeability Assay Based on Supramolecular Fluorescent Artificial Receptors (Frontiers in Chemistry, 2020)

Predicting a Drug’s Membrane Permeability (The Journal of Physical Chemistry B, 2017)

A Hydrogel-based Assay for the Fast Prediction of Antibiotic Accumulation in Gram-negative Bacteria (Materials Today Bio, 2020)

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