Virulence, therapy

This is therapy that focuses on interfering with bacterial virulence factors instead of central growth pathways to treat a disease.

Drugs used in virulence therapy are called antivirulence drugs. These have been approved for bacterial toxin-mediated diseases. Antivirulence strategies pose unique challenges for drug development and clinical use. They are mainly pathogen-specific approaches and may need to be used as adjuncts to antibiotics.

Different Drugs for Bad Bugs: Antivirulence strategies in the age of antibiotic resistance (Nature Reviews Drug Discover, 2017)

Editorial: Antivirulence Drugs Against Bacterial Infections (Frontiers in Microbiology, 2021)

The concept for the antivirulence therapeutics approach as alternative to antibiotics: hope or still a fiction? (Biotechnology and Biotechnological Equipment, 2022)