Druglikeness

Druglikeness refers to the similarity of the properties between compounds and existing drugs.

Druglike compounds are more likely to be transformed into drugs. Descriptors of druglikeness include the classic Rule of Five (Ro5) as originally proposed by Lipinski which describes molecular properties important for a drug’s pharmacokinetics in the human body. This include intrinsic properties of a compound that will lead to favourable ADME (absorption, distribution, metabolism and excretion) characteristics.

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings (Advanced Drug Delivery Reviews, 1997)

SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules (Scientific Reports, 2017)

Understanding Drug-likeness (Wires Computational Molecular Science, 2011)

Rule of 5 (pharmainformatic.com)