A murine pneumonia model is an experimental infection system in which pneumonia is induced in mice to study the pathogenesis of respiratory pathogens and to evaluate the efficacy of antimicrobial agents.
The model is generated by infecting a mouse with respiratory pathogens such as Streptococcus pneumoniae, Klebsiella pneumoniae, Pseudomonas aeruginosa, or Acinetobacter baumannii through inoculation of the nose or trachea. The model replicates key features of human lung infection, including bacterial proliferation, inflammation, and lung tissue damage, allowing researchers to investigate host–pathogen interactions and therapeutic responses. It is widely used in preclinical research to assess pharmacokinetics and pharmacodynamics of antibiotics, test novel therapeutic strategies, and explore immune mechanisms relevant to pneumonia.