Collateral sensitivity

Antibiotic resistance to one antibiotic confers increased susceptibility to another antibiotic.

Collateral sensitivity is an evolutionary trade-off between antibiotic resistance mechanisms in bacteria and depend on the local environmental conditions. The clinical application of collateral sensitivity remains unclear.

Collateral sensitivity associated with antibiotic resistance plasmids (eLife, 2021)

Collateral sensitivity interactions between antibiotics depend on local abiotic conditions (mSystems, 2021)

Mechanisms and therapeutic potential of collateral sensitivity to antibiotics (PLoS Pathogens, 2021)