Druglikeness refers to the similarity of the properties between compounds and existing drugs.

Druglike compounds are more likely to be transformed into drugs. Descriptors of druglikeness include the classic Rule of Five (Ro5) as originally proposed by Lipinski which describes molecular properties important for a drug’s pharmacokinetics in the human body. This include intrinsic properties of a compound that will lead to favourable ADME (absorption, distribution, metabolism and excretion) characteristics.