A group of bacteria – Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter spp – that are the leading cause of hospital-acquired infections globally. Variations to ESKAPE exist, with ‘E’ standing for Escherichia coli, Enterobacteriaceae, or Enterobacterales. Clinically, these bacteria are important because they are common, often multidrug-resistant and difficult to treat.