Metabolism testing

Characterizing the metabolism of a compound as part of the ADME (drug absorption, distribution, metabolism and excretion) determination.

The metabolic biotransformation of small-molecule drugs is an important aspect of the drug discovery process and in clinical pharmacology. It is a key determinant of elimination and toxicity in humans.

Drug metabolism in preclinical drug development: a survey of the discovery process, toxicology, and computational tools (Current Drug Metabolism, 2018)

Prediction of drug metabolism and interactions on the basis of in vitro investigations (Basic & Clinical Pharmacology & Toxicology, 2005)

Pharmacokinetics and drug metabolism of antibiotics in the elderly (Expert Opinion on Drug Metabolism & Toxicology, 2018)