Definition:
Analysis whereby participants who do not initiate treatment are excluded from the analysis.
There are no clear definitions of what a mITT is and descriptions of mITT analyses vary greatly from trial to trial. In contrast, the intention-to-treat (ITT) principle is more controlled. An ITT requires that all participants are randomised and that they must be included in the final analysis. The participants should be analysed according to the treatment group to which they were originally assigned to, regardless of the treatment received, withdrawals, lost to follow-up or cross-overs.
Trials with an mITT analysis have a majority of post-randomisation exclusions, industry sponsorship and favourable findings.
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