Monte Carlo Simulation (MCS)

A Monte Carlo simulation is a mathematical technique that simulates the range of possible outcomes for an uncertain event.

MCS generates predictions based on an estimated range of values evolving randomly instead of a fixed set of values. In antibacterial drug development, MCS is used to generate data for pharmacokinetic-pharmacodynamic (PK-PD) target attainment analyses to assess antibacterial dosing regimens early on.

Use of Monte Carlo Simulation and Considerations for PK-PD Targets to Support Antibacterial Dose Selection (Current Opinion in Pharmacology, 2017)