Definition:
Pharmacogenetics is the study of how a person’s genes affect the way they respond to drugs specific gene mutations, whereas pharmacogenomics study the simultaneous impact of multiple mutations in genes in the genome that may determine a patient’s response to drug therapy.
Pharmacogenetics and pharmacogenomics are tools of translational medicine and may identify patient sub-populations that respond better to a treatment exhibit more effective responses and/or an improved safety profile upon treatment.
Many antibiotics are not substrates of the major hepatic biotransformation pathways. An example of pharmacogenetics is where variants in of some drug transporters, involved in the cellular transport of antibiotics, occur and these can be associated with interindividual variability in the clearance and effects of these drugs.
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