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Building better breakpoints: data and methods needed to determine breakpoints for new agents


Speakers: 

John Turnidge, Scientific Secretary, European Committee on Antimicrobial Susceptibility Testing and Clinical Professor, Adelaide Medical School, University of Adelaide (Australia) 

Anouk Muller, Clinical Microbiologist, Haaglanden Medical Center, Netherlands and Erasmus University Medical Center, (Netherlands)

Moderator: Gunnar Kahlmeter, EUCAST

In this webinar, John Turnidge and Anouk Muller discussed how to determine breakpoints for new agents. The following topics were discussed:

  • Preclinical data and methods: MIC distributions, ECOFFs, in vitro models, in vivo models, initial PK/PD parameters and targets
  • Clinical data and methods: human PK, Monte Carlo Simulation, Target Attainment Rates, clinical outcome studies

The presentations were followed by a Q&A session.


This live webinar including interactive Q&A session was broadcast on 21 October 2020.

If you have questions or comments, please let us know: revive@gardp.org.

2020-10-22T08:50:40+00:00