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Adaptive trial

Definition:

A clinical trial that can be modified mid-way through based on preliminary analysis of results.

Adaptive trials are efficient ways of testing more than one drug at a time, or different doses of a drug. If initial data suggest that a treatment is not working, or is inferior to a comparator, recruitment into that treatment arm can be halted.

Adaptive trials were pioneered in oncology but are increasingly being used in other areas of medicine.