Removal of a substance from the body by the kidney and its excretion in urine.

In pharmacologic terms, it is a pharmacokinetic measurement of the volume of plasma from which a substance is completely removed per unit time.

Renal clearance is the principal route through which most drugs are removed from the body. Dosing of antibiotics may need to be adjusted in people with impaired renal function, as some antibiotics are toxic at high concentrations.