Semi-synthetic antibiotics are compounds that are chemically derived from the natural antibiotics.

Oritavancin, telavancin and dalbavancin are examples of semisynthetic antibiotics. Semisynthetic antibiotics have improved pharmaceutical properties compared to their natural parent, making them more suitable for clinical use. Semisynthetic antibiotics provide a source of therapeutic candidates in the current global need to overcome antimicrobial resistance.

See also: Natural product vs (semi-)synthetic compounds