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PK-PD in support of accelerated programmes: how much is enough?

William Hope

Date : April 22, 2018

This presentation was part of the educational workshop:

‘Expediting antibacterial development: core lessons and key tools for a rocky road’

at the 28th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Madrid, April 21-24, 2018

Co-organized by: GARDP – Global Antibiotic Research Development Partnership, CARB-X – Combating Antibiotic Resistant Bacteria Biopharmaceutical Accelerator

Chair persons: William Hope and Sumathi Nambiar

Introduction: In order to speed up antibacterial development programmes it’s important to be aware of the regulatory tools involved. PK-PD modelling and simulation can be used as an ‘applied science’ tool to provide answers on the efficacy and safety of new drugs faster and at a lower cost but to what extent should this be used to accelerate programmes? Finally the workshop looks at alternatives to (classical) antibiotics and asks what it will take to convincingly develop a virulence inhibitor or similar indirect agent.

2018-07-31T08:52:14+00:00