Hit

A compound or extract identified in an initial screen for antibacterial activity. A hit must be re-tested to confirm its activity (see: ‘Hit confirmation, hit validation‘).

See also: Hit-to-lead (HTL), lead generation, Hit identification, hit discovery, Hit expansion.

Discovery and preclinical development of new antibiotics (Upsala Journal of Medical Sciences, 2014)

Principles of early drug discovery (British Journal of Pharmacology, 2010)

Video: 7 Steps to Drug Discovery (ACS Webinars, 2014)