Definition:

The lowest concentration of an antibiotic that prevents the visible growth of bacteria.

Potent antibiotics, therefore, have low MIC values. As bacteria become less susceptible to an antibiotic, MIC values increase.

To categorize microbes as drug-resistant, the MIC values are compared with standardized recommended breakpoint concentrations.

 

Video definition of MIC by Laura Piddock, GARDP (Switzerland).
Video definition of measuring MIC by Alexander Lepak, University of Wisconsin School of Medicine and Public Health (USA).

Videos:
More information:

Minimum Inhibitory (MIC) and Minimum Bactericidal Concentration (MBC) Evaluations as R&D Tools (Q Laboratories, 2020)

Variation of MIC measurements: the contribution of strain and laboratory variability to measurement precision (Journal of Antimicrobial Chemotherapy, 2018)

MIC determination of non-fastidious and fastidious organisms (EUCAST, 2020)

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Definition, Encyclopaedia, Expert video, Publication, Video, Discovery, Exploratory, Hit-to-lead, Lead-to-candidate, Phase 1, Phase 2, Phase 3, Phase 4, PK/PD, Preclinical development, Screening, Toxicology